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Versatile biomanufacturing through stimulus responsive cell-bacteria feedback

發布日期:2018-12-18訪問次數: 信息來源:動物醫學院字號:[ ]


報告題目Versatile biomanufacturing through stimulus responsive cell-bacteria feedback

 

報告人:Dr. Zhuojun Dai

 

時間:20181221日,上午10:30

 

地點:動醫動科大樓0103會議室

 

聯系人:朱奎,曲少奇

 

電話:15600780227,13969675245

 

報告人簡介

戴卓君,副研究員,目前在中國科學院深圳先進技術研究院工作,于浙江大學獲得學士學位,于香港中文大學化學系獲得博士學位(Ph.D advisor: Prof Chi Wu),之后在美國杜克大學生物醫學工程系從事博士后研究(Postdoc advisor, Prof Lingchong You)。在PNAS, Biomaterials, Macromolecules, Journal of Controlled release 等雜志發表文章十余篇。實驗室目前的主要研究方向是利用高分子化學與物理的手段,結合合成生物學解決一系列理論及應用問題。比如利用刺激敏感性水凝膠與工程菌群的雙向反饋實現下游蛋白純化,篩選等多角度,模塊化應用;集合蛋白質工程與材料設計實現活性材料生產等。

 

Abstract

Small-scale production of biologics has great potential in facilitating individualized medicine and enhancing the accessibility of biomanufacturing. By exploiting cell-material feedback, we designed a concise platform to achieve versatile production, analysis, and purification of diverse proteins and protein complexes. The core of our technology is a microbial swarmbot, which consists of a stimulus-sensitive polymeric microcapsule encapsulating engineered bacteria. By sensing the confinement, the bacteria undergo programmed partial lysis at a high local density. Conversely, the encapsulating material shrinks in response to the changing chemical environment caused by cell growth and death, squeezing out the protein products released from bacterial lysis. This platform is then integrated with downstream modules to enable quantification of enzymatic kinetics, purification of diverse proteins, quantitative control of protein interactions, and assembly of functional protein complexes and multi-enzyme metabolic pathways through division of labor. Our work demonstrates the use of the feedback between living cells and materials to engineer a modular and flexible platform with sophisticated yet well-defined programmed functions.

 

 

 

 

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